Premier Laboratorys Pharmacology Capabilities

In addition to our comprehensive histology capabilities, we offer preclinical pharmacology services to support our clients’ product discovery and development activities. We work with our customers to design pharmacology studies with the researchers endpoint in mind, and we offer both routine and special necropsy procedures to suite our customers’ needs.

Inflammation

• H & E
• Oxazalone-induced delayed type hypersensitivity in mice
• TPA-induced ear edema in mice

Cancer and angiogenesis

• Xenografts
• Corneal neovascularization

Pharmacokinetic and toxicology

• Pharmacokinetic testing
• Pilot toxicology

Other models

• Cyclophosphamide-induced neutropenia
• Diet-induced non-insulin dependent diabetes mellitus
• Spontaneous type II diabetes mellitus
• Dexamethasone-induced weight loss
• Evaluation of hematopoietic agents
• Growth hormone replacement therapy in hypophysectomized rats

Transgenic phenotyping pathology

The Effects of Cytoxan on Male Sprague Dawley Rats